论文部分内容阅读
目的:观察重组人表皮生长因子(rhEGF,金因肽)治疗腺周口疮(maRAU)的疗效。方法:将30例maRAU患者采用随机平行对照试验。对照组给予常规药物2.5%醋酸泼尼松龙局部封闭治疗,实验组则在溃疡面上涂rhEGF凝胶。两组均治疗至溃疡愈合或2周止。记录溃疡愈合时间和疼痛消失时间。观察愈合后的组织缺损情况和1年内的复发情况。结果:实验组溃疡平均愈合时间(5.5±1.29)d,对照组(8.6±2.07)d,两组比较,差异有统计学意义(P<0.05)。两组患者在疼痛消失时间和总有效率上无显著性差异(P>0.05),但在愈合后的组织缺损和1年内复发率上有显著性差异(P<0.05)。结论:rhEGF凝胶对maRAU创面具有明显的促进愈合作用,使用方便、安全,且愈合后组织缺损少,复发率低,容易被患者接受。
Objective: To observe the effect of recombinant human epidermal growth factor (rhEGF) in the treatment of marau. Methods: Thirty patients with maRAU were randomized and controlled. The control group was treated with conventional drugs 2.5% prednisolone local closed treatment, while the experimental group was coated with rhEGF gel on the ulcer surface. Both groups were treated until ulcer healing or 2 weeks. Record ulcer healing time and pain disappear time. Observe the healing of tissue defects and recurrence within 1 year. Results: The ulcer average healing time (5.5 ± 1.29) days in experimental group and control group (8.6 ± 2.07) days, the difference was statistically significant (P <0.05). There was no significant difference between the two groups in the time of pain disappearance and the total effective rate (P> 0.05), but there was a significant difference (P <0.05) between the healing rate of tissue defect and the recurrence rate within one year. Conclusion: rhEGF gel has obvious healing effect on maRAU wounds. It is convenient and safe to use and has less tissue defects and low recurrence rate after healing. It is easy to be accepted by patients.