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目的探讨红细胞分布宽度(RDW)与冠心病合并阻塞性睡眠呼吸暂停(OSA)患者严重程度关系。方法将165例OSA患者根据睡眠呼吸暂停低通气指数(AHI)分为对照组(AHI<5次/h)37例,轻度OSA组(5≤AHI≤15次/h)35例,中度OSA组(1530次/h)43例。采用血液分析仪测定患者RDW,同时采用胶乳增强免疫透射比浊法测定高敏C反应蛋白(hs-CRP)水平。比较不同组患者RDW和hs-CRP水平,分析RDW与OSA患者AHI相关性。结果重度组患者RDW(14.3%)明显高于中度组(13.6%)、轻度组(13.3%)和对照组(12.4%),四组之间比较差异有统计学意义,(P<0.05);对照组、轻度组、中度组和重度组患者hs-CRP水平分别为3.5、3.9、5.0和6.1 mg/L,组间差异有统计学意义(P<0.05);RDW与AHI、氧减指数、hs-CRP呈正相关(r值分别0.375、0.276和0.182,P均<0.05),Logistic回归分析显示RDW是OSA的独立危险因素之一(OR=1.56,95%CI:1.231~2.012,P<0.05)。结论 RDW是OSA的独立危险因素之一,并可作为OSA严重程度评价指标之一。
Objective To investigate the relationship between RDW and severity of obstructive sleep apnea (OSA) in patients with coronary heart disease. Methods A total of 165 patients with OSA were divided into control group (AHI <5 times / h), OSA group (35≤AHI≤15 times / h), moderate hypodermic 50 cases in OSA group (15 30 times / h). The RDW was measured by hematology analyzer, and the level of hs-CRP was measured by latex enhanced immunoturbidimetry. The levels of RDW and hs-CRP in different groups were compared and AHI was analyzed between RDW and OSA. Results The RDW in severe group was significantly higher than that in moderate group (13.6%), mild group (13.3%) and control group (12.4%), the difference was statistically significant (P <0.05 ). The hs-CRP levels were 3.5, 3.9, 5.0 and 6.1 mg / L in the control group, mild group, moderate group and severe group respectively. There was significant difference between the two groups (P <0.05) (R = 0.375, 0.276 and 0.182 respectively, all P <0.05). Logistic regression analysis showed that RDW was one of the independent risk factors of OSA (OR = 1.56, 95% CI: 1.231 ~ 2.012 , P <0.05). Conclusion RDW is one of the independent risk factors of OSA and can be used as one of the evaluation indicators of OSA severity.