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目的探讨体外受精-胚胎移植周期中单卵双胎发生率和相关原因。方法回顾性分析2006年1月至2009年5月间广州医学院第三附属医院生殖助孕科行常规体外受精-胚胎移植(IVF-ET)、卵胞浆内单精子显微注射术(ICSI)和冻融胚胎移植术(TET)后发生单卵双胎(MZT)患者的临床资料。统计MZT的发生率、流产率,分析常规IVF周期和ICSI周期、新鲜周期和冻融周期以及不同移植天数与单卵双胎妊娠发生率之间的关系。结果获临床妊娠1625个周期中,单卵双胎妊娠15例,发生率为0.92%,5例(33.3%)流产。比较单卵双胎组和非单卵双胎组患者年龄、不孕时间、促排时间、促性腺激素类似物(Gn)用量、获卵数、受精数和移植胚胎数,差异均无统计学意义(P>0.05)。常规IVF周期和ICSI周期、新鲜周期和冻融周期以及不同移植天数中MZT的发生率在各组间差异均无统计学意义(P>0.05)。结论体外受精-胚胎移植周期中MZT发生率高于自然周期妊娠。单纯的ICSI操作、冻融过程和移植天数与MZT的发生率的增加无紧密联系。
Objective To investigate the incidence and related causes of monozygotic twins in IVF-ET cycles. Methods The clinical data of IVF-ET and intracytoplasmic sperm injection (ICSI) were analyzed retrospectively from January 2006 to May 2009 in the Third Affiliated Hospital of Guangzhou Medical College. ) And clinical data of monozygotic twins (MZT) patients after frozen-thawed embryo transfer (TET). Statistics MZT incidence, abortion rate, analysis of conventional IVF cycle and ICSI cycle, fresh cycle and freeze-thaw cycle, and the number of days of transplantation and the relationship between the incidence of monozygotic twins pregnancy. Results 1625 cycles of clinical pregnancy, 15 cases of monozygotic twin pregnancy, the incidence was 0.92%, 5 cases (33.3%) abortion. Comparing the age, infertility time, promoting time, the amount of gonadotropin (Gn), the number of oocytes retrieved, the number of fertilized and the number of embryos transferred, no difference was found between the two groups Significance (P> 0.05). There was no significant difference in the incidence of MZT between routine IVF cycles, ICSI cycles, fresh cycles, freeze-thaw cycles, and days of transplantation (P> 0.05). Conclusion The incidence of MZT in IVF-ET cycles is higher than that in spontaneous cycles. Simple ICSI procedures, freeze-thaw cycles and days of transplantation were not associated with an increased incidence of MZT.