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目的 分析多发性骨髓瘤患者发生医院感染的情况。方法 对 119例多发性骨髓瘤患者发生的医院感染进行回顾性分析 ;将患者分为粒细胞缺乏组 (粒缺组 )和非粒细胞缺乏组 (非粒缺组 )。结果 119例中 34例发生医院感染 ,感染率 2 8.5 7% ;医院感染率粒缺组 83.33% ,非粒缺组 2 2 .4 3% (P<0 .0 0 5 ) ,粒缺组死亡率 16 .6 7% ,非粒缺组 2 8.3% (P<0 .0 1) ;人均感染日粒缺组 10 .3d,非粒缺组 5 .75 d(P<0 .0 5 ) ;感染部位以下呼吸道为主 ;医院感染的病原菌以革兰阴性杆菌为主。结论 粒细胞缺乏是多发性骨髓瘤患者发生医院感染的主要危险因素 ,缩短白细胞减少的持续时间 ,有效的预防措施 ,早期、合理应用敏感的抗生素是减少医院感染的主要方法
Objective To analyze the incidence of nosocomial infections in patients with multiple myeloma. Methods A retrospective analysis was performed on nosocomial infections in 119 patients with multiple myeloma. The patients were divided into agranulocytosis group and non-agranulocytosis group. Results Among 119 cases, 34 cases had nosocomial infection with an infection rate of 2 8.57%. The nosocomial infection rate was 83.33% in the nosocomial infection group and 22.34% in the non-nociceptive group (P <0.05) Rate of 16.76%, non-lacking group 2 8.3% (P <0.01); per capita infection of day grain lacking group 10.3d, non-lacking group 5.75d (P <0.05); The main respiratory tract infection below the site; pathogenic bacteria in hospital-based gram-negative bacilli. Conclusions Agranulocytosis is the main risk factor of nosocomial infection in patients with multiple myeloma. Shortening the duration of leukopenia and effective preventive measures, early and rational use of sensitive antibiotics is the main method to reduce nosocomial infection