【摘 要】
：
Cells regulate phospholipase D (PLD) activity in response to numerous extracellular signals. Here, we investigated the involvement of PLD activity in transformi
【机 构】
：
State Key Laboratory of Molecular Biology
论文部分内容阅读
Cells regulate phospholipase D (PLD) activity in response to numerous extracellular signals. Here, we investigated the involvement of PLD activity in transforming growth factor-β(TGF-β1)-mediated growth inhibition of epithelial cells. TGF-β1 inhibits the growth of MDCK, Mv1Lu, and A-549 cells. In the presence of 0.4 % butanol, TGF-β1 induces an increase in the formation of phosphatidylbutanol, a unique product catalyzed by PLD. TGF-β1 also induces an increase in phosphatidic acid (PA) level in A-549 and MDCK cells. TGF-β1 induces an increase in the levels of DAG labeled with [3H]-myristic acid in A-549 and MDCK cells but not in Mv1Lu cells. No increase of DAG was observed in cells prelabeled with [3H]-arachidonic acid.The data presented suggest that PLD activation is involved in the TGF-β1-induced cell growth inhibition.
其他文献
文中在TI Davinci平台的基础上研究了安全VoIP视频电话终端的设计与实现,通过研究SIP通信中存在的注册劫持、服务器伪装、消息篡改等一系列安全威胁,针对SIP的安全问题改进了
To study the effect of glutamate on the intracellular calcium signal of pure cultured ratastrocytes and the role of NMDA and AMPA receptors in the procedure, th
To investigate the effects of mycophenolate mofetil MMF) on the process of renal inter-stitial fibrosis,unilateral ureteral obstruction (UUO) model was establis
The expression of glucose regulated protein 94 (GRP94)during the treatment of human colorectal carcinoma cell lineClone A cells with sodium butyrate was studied
INTRODUCTION The antitumor activity of norcantharidin (NCTD),the demethylated analogue of cantharidin, was studied in the early 1980s in China. NCTD has no side
The study was designed to compare the combustion products of coal gas, liquefied petroleum gas and natural gas in relation to indoor air pollution. Methods Regu
INTRODUCTIONEsophageal hematomas develop from the dissectionof the mucosa from the muscular layers of theesophageal wall and represent an uncommoncondition aff
Objective: To review the diagnosis and differential diagnosis of inflammatory fibroid polyp (IFP) of gastrointestinal tract. Methods: The clinical symptoms, his
INTRODUCTIONVascular endothelial growth factor (VEGF) which is also known as vascular permeability factor (VPF) is a heparin-binding, dimeric polypeptide growth
随着网络技术的快速发展,网络入侵事件的发生也渐渐的增多。从网络安全立体、纵深、多层次防御的角度出发,入侵检测系统和技术得到的高度重视。另议方面随着技术的发展,网络