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12名健康者,单独服用狄戈辛和服硫氮革酮(diltiazem,180mg/日)+狄戈辛,以研究硫氮(艹卓)酮对狄戈辛在稳态时的代谢动力学变化。硫氮(艹卓)酮使狄戈辛的血清浓度增高约20%,AUC(药—时曲线下面积)显著增大,48小时时为+22.24%;到试验结束时为+40.92%。半衰期由36.7小时延长为44.46小时(+
Twelve healthy people took dioxin and diltiazem (180 mg / day) + Digoxin respectively to study the metabolic dynamics of dioxin at home. Sulfanilamide increased the concentration of Digoxigenin by about 20% in serum. The AUC (area under the drug-time curve) increased significantly, + 22.24% at 48 hours and + 40.92% at the end of the study. The half-life increased from 36.7 hours to 44.46 hours (+