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[目的]明确高危型人乳头瘤病毒基因(HR-HPV DNA)检测在诊断宫颈上皮内瘤变(CIN)中的意义.[方法]选取196例进行HPV DNA检测并经组织学诊断为CIN的患者资料进行分析.[结果]HR-HPV DNA在CINⅠ,CINⅡ,CINⅢ级中的阳性表达率分别为88.63%(39/44),90.00%(36/40),93.75%(105/112),三者之间差异具有统计学意义(P<0.05);且HR-HPV的阳性表达率随着宫颈病变的级别上升呈逐渐增高的趋势.[结论]HR-HPV DNA检测对CIN诊断有重要价值.
[Objective] To clarify the significance of detection of HR-HPV DNA in diagnosis of cervical intraepithelial neoplasia (CIN). [Methods] 196 cases were selected for HPV DNA detection and histologically diagnosed as CIN The positive rates of HR-HPV DNA in CINⅠ, CINⅡ and CINⅢwere 88.63% (39/44), 90.00% (36/40) and 93.75% (105/112) respectively. The positive rates of HR- (P <0.05). The positive expression rate of HR-HPV increased with the increase of cervical lesions. [Conclusion] The detection of HR-HPV DNA is of great value in the diagnosis of CIN .