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目的了解广州地区淋球菌对7种抗生素耐药性及PPNG和TRNG的流行状况。方法用琼脂稀释法测定头孢曲松、头孢克肟、青霉素、大观霉素、环丙沙星、阿奇霉素和四环素的最低抑菌浓度(MIC);用纸片碘量法检测β-内酰胺酶。结果 100株淋球菌检出PPNG 33株(33%)、TRNG 40株(40%),青霉素、环丙沙星、阿奇霉素的耐药率分别为93%,98%,17%,检出环丙沙星高度耐药株42株(42%),未发现头孢曲松、头孢克肟耐药菌株,但其低敏率分别为12%,11%,未发现大观霉素耐药菌株和低敏菌株。结论广州地区分离淋球菌对青霉素、环丙沙星耐药严峻,但对头孢曲松、头孢克肟、大观霉素均敏感,需对药物耐药性进行动态监测以指导临床合理应用抗菌素。
Objective To understand the resistance of Neisseria gonorrhoeae to seven antibiotics and the prevalence of PPNG and TRNG in Guangzhou area. Methods The minimum inhibitory concentration (MIC) of ceftriaxone, cefixime, penicillin, spectinomycin, ciprofloxacin, azithromycin and tetracycline was determined by agar dilution method; β-lactamase was detected by iodoform method. Results 100 strains of Neisseria gonorrhoeae detected PPNG 33 (33%), TRNG 40 (40%), penicillin, ciprofloxacin, azithromycin resistance rates were 93%, 98%, 17% Forty-two (42%) of the highly resistant SHXS strains were found ceftriaxone and cefixime-resistant strains, but their low sensitivity rates were 12% and 11% respectively. No spectinomycin-resistant strains and low-sensitivity Strain. Conclusion Neisseria gonorrhoeae isolates from Guangzhou have severe resistance to penicillin and ciprofloxacin, but are sensitive to ceftriaxone, cefixime and spectinomycin. The drug resistance of the Neisseria gonorrhoeae should be dynamically monitored to guide the rational use of antibiotics.