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目的探讨胎盘绒毛膜血管瘤的临床和病理特点、诊断和鉴别诊断,提高对该肿瘤的认识。方法对3例胎盘绒毛膜血管瘤进行临床病理和免疫组化观察,并进行文献分析。结果镜下表现为大量增生的毛细血管样血管,局灶血管扩张呈海绵状血管瘤样,伴有黏液变、凝固性坏死及钙化,瘤细胞CD34(+)。结论胎盘绒毛膜血管瘤是一种少见的胎盘良性肿瘤,病理形态类似于其他部位的血管瘤,常常引起羊水过多、胎儿水肿、心功能衰竭、贫血等症状,但目前尚无规范的处理方法。
Objective To investigate the clinical and pathological features, diagnosis and differential diagnosis of placental choriocarcinoma and to raise awareness of the tumor. Methods Three cases of placental choriocarcinoma were observed by clinicopathological and immunohistochemical methods and analyzed by literature. Results The microscopic appearance showed a large number of proliferating capillary vessels with cavernous hemangiomas in the dilated focal vessels accompanied by mucinous changes, coagulation necrosis and calcification, and tumor cells CD34 (+). Conclusion Placental choriocarcinoma is a rare benign tumor of the placenta and its pathological morphology is similar to that of other hemangiomas. It often causes polyhydramnios, fetal edema, heart failure and anemia. However, there is no standardized treatment .