目的 :检测表皮生长因子 (mEGF)在口腔局部用药制剂中活性和热稳定性。方法 :采用四甲基偶氮唑盐微量酶反应比色法。结果 :mEGF在对不同温度活性比较中作t检验 ,各组间无统计学差异。结论 :表皮生长因子是一种高度生物活性多肽物质 ,因结构紧密 ,对热比较稳定 ,是所有细胞生长因子中唯一能耐受热的一种生物活性蛋白质 ,在加入朵贝氏溶液中无抑制活性作用 Objective: To determine the activity and thermostability of epidermal growth factor (mEGF) in oral topical preparations. Methods: Tetramethylazolamide trace enzyme reaction colorimetric method. Results: mEGF in the different temperature activity for t test, no significant difference between the groups. Conclusion: Epidermal growth factor (EGF), a highly bioactive peptide, is the only biologically active protein among all cell growth factors that is heat-tolerant because of its compact structure and relatively stable heat. It has no inhibitory activity in Duob’s solution