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目的:分析降糖药致药品不良反应(ADR)的特点和规律,促进该类药物的合理应用。方法:收集我院2006年1月-2013年8月上报的降糖药致ADR报告359例,并对患者性别与年龄、药品种类、ADR累及器官或系统等情况进行统计和分析。结果:发生ADR的患者多为51岁以上的中老年人;涉及降糖药7类23种,其中磺酰脲类引发ADR最多,共90例,占25.07%;口服是ADR病例的主要给药途径;造成的损害累及10个器官或系统类型,胃肠道反应所占比例最大(占30.08%);给予相应处理后痊愈或好转的患者共341例,占94.99%;68.25%的ADR报告关联性评定为“很可能”。结论:降糖药引发的ADR较为常见,临床应用时应加强监护、及时处理,以确保用药的安全,提高治疗水平。
OBJECTIVE: To analyze the characteristics and laws of ADR induced by hypoglycemic agents and to promote the rational use of such drugs. Methods: A total of 359 ADR cases reported in our hospital from January 2006 to August 2013 were collected and analyzed for gender and age, type of drug, ADR involved organ or system. Results: Most ADR patients were middle-aged and older than 51 years old. There were 23 kinds of 7 kinds of hypoglycemic agents. Among them, sulfonylureas caused the most ADRs, 90 cases accounted for 25.07%. Oral administration was the main drug for ADR cases The pathological changes caused by the damage were caused by 10 organs or system types, and the gastrointestinal reaction accounted for the largest proportion (30.08%). A total of 341 patients (94.99%) were cured or improved after corresponding treatment, and 68.25% were associated with ADR Sex rated as “most likely”. Conclusion: ADR induced by hypoglycemic agents is more common, clinical application should be strengthened care, timely treatment to ensure the safety of medication, improve the level of treatment.