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目的 :研究心肌肌钙蛋白 T(cardiac troponin T,c Tn T)在心肌炎中的动态变化及与心功能的相关性。方法 :应用夹心层免疫吸附法测定 30例心肌炎 ,2 0例疑似心肌炎及 30例正常对照 c Tn T和肌酸磷酸激酶 (creatinekinase,CK)及同功酶 CK - MB,同步进行心功能测定。结果 :心肌炎组 c Tn T明显高于疑似心肌炎组及对照组 ,且心肌炎组治疗前明显高于治疗后 ,疑似心肌炎组与对照组无显著差异。 c Tn T与心脏收缩功能 (CI,EF,ACT)均呈负相关。 c Tn T的敏感性为 76 .6 7% ,特异性为 96 .6 7%。结论 :c Tn T对心肌损害的敏感性及特异性均高于 CK和 CK-MB,其动态变化提示心肌病变的轻重及预后。 c Tn T与心脏收缩功能呈负相关 ,即 c Tn T越高 ,收缩功能越差。
Objective: To study the dynamic changes of cardiac troponin T (cTn T) in myocarditis and their correlation with cardiac function. Methods: Thirty cases of myocarditis, 20 cases of suspected myocarditis and 30 cases of normal control cTn T, creatine kinase (CK) and isoenzyme CK - MB were measured by sandwich immunoassay. Cardiac function was measured synchronously. Results: The level of cTn T in myocarditis group was significantly higher than that in suspected myocarditis group and control group. The level of cTn in myocarditis group before treatment was significantly higher than that in control group. There was no significant difference between the group of suspected myocarditis and the control group. c Tn T was negatively correlated with cardiac contractile function (CI, EF, ACT). The sensitivity of cTn T was 76.67% and the specificity was 96.67%. CONCLUSION: The sensitivity and specificity of cTn T to myocardial damage are higher than that of CK and CK-MB. The dynamic changes of cTn T indicate the severity and prognosis of myocardial lesions. cTn T and cardiac contractile function was negatively correlated, that cTn T higher, the worse the systolic function.