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目的:总结阑尾类癌的临床病理特征及免疫组化特点探讨其组织起源、临床病理特点、鉴别诊断及其预后。方法:回顾性分析本院1987年1月~2012收治的6例阑尾类癌的临床和病理资料,并进行光镜和免疫组化观察和嗜银染色观察。结果:6例术前临床误诊为阑尾炎,所有患者均经病理确诊。肿块位于阑尾末端4例,体部2例。光镜下癌细胞大小、形状、染色较一致,排列呈巢团状、缎带状、腺泡状、水纹状、假腺样等。6例CgA及NSE、Syn及NSE均阳性。1混合型例CK、CEA、EMA阳性。嗜银染色阳性。结论:阑尾类癌临床表现及体征缺乏特异性,确诊靠术后病理检查。预后一般良好。阑尾类癌是消化道类癌最常见的肿瘤之一。大约有19%的类癌发生在阑尾[1],阑尾类癌在临床上缺乏特异性的症状和体征多数在阑尾炎和其他腹腔手术时发现。本文回顾性分析6例。
OBJECTIVE: To summarize the clinicopathological features and immunohistochemical characteristics of appendix carcinoid and discuss the origin, clinicopathological characteristics, differential diagnosis and prognosis of the appendix carcinoid. Methods: The clinical and pathological data of 6 cases of appendix carcinoid tumors in our hospital from January 1987 to 2012 were analyzed retrospectively. The results of light microscopy and immunohistochemistry and silver staining were observed. Results: 6 cases of preoperative clinical misdiagnosed as appendicitis, all patients were pathologically confirmed. The lumps were located in the distal end of the appendix in 4 cases and in the body in 2 cases. Light microscope, the size of the cancer cells, shape, dyeing more consistent, arranged in clusters were nest, ribbons, acinar, watery stripes, such as pseudo-gland. 6 cases of CgA and NSE, Syn and NSE were positive. 1 mixed type CK, CEA, EMA positive. Argyrophilic staining. Conclusion: Clinical manifestations and signs of appendix carcinoid lack specificity, diagnosis by postoperative pathological examination. The prognosis is generally good. Appendelic carcinoid is one of the most common tumors of gastrointestinal carcinoid. Approximately 19% of carcinoid tumors occur in the appendix [1]. Clinical signs and symptoms of appendicant carcinoids are mostly found in appendicitis and other abdominal operations. This article retrospectively analyzed 6 cases.