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目的:探讨原发性高血压(EH)患者与超敏C反应蛋白(hs-CRP)及纤维蛋白(FIB)的关系。方法:对106例高血压患者和50例健康体检者同时检测hs-CRP、FIB,采用乳胶增强透射比浊法测定hs-CRP,用clauss法检测FIB。结果:hs-CRP水平各级EH患者间比较均有显著性差异(P<0.01);血浆FIB水平在I级EH时不明显(P>0.05),II级和III级时显著升高(P<0.05;P<0.01),II级EH时的水平与I级时比较差异不明显(P>0.05)。EH患者血浆hs-CRP、FIB二项指标之间有良好的相关性(r=0.697,P<0.01)。结论:hs-CRP、FIB作为急性时相反应蛋白,可反映出机体炎症活性,在原发性高血压的发病机制中可能起一定作用。
Objective: To investigate the relationship between high-sensitivity C-reactive protein (hs-CRP) and fibrin (FIB) in patients with essential hypertension (EH). Methods: hs-CRP and FIB were detected simultaneously in 106 hypertensive patients and 50 healthy volunteers. The hs-CRP was measured by latex enhanced turbidimetry. The FIB was detected by clauss method. Results: The levels of hs-CRP in all levels of EH patients were significantly different (P <0.01). The levels of plasma FIB were not significantly different in EH patients (P> 0.05) <0.05; P <0.01). The level of EH at grade II was not significantly different from that at level I (P> 0.05). EH patients with plasma hs-CRP, FIB two indicators between the good correlation (r = 0.697, P <0.01). Conclusion: hs-CRP and FIB, as acute phase reaction proteins, can reflect the inflammatory activity of the body and may play a role in the pathogenesis of essential hypertension.