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应用免疫酶标技术对47例异体肾移植患者的95例次肾活检标本进行HLA-DR抗原的检测,并同时做光镜、电镜、免疫病理检查及淋巴细胞亚群的研究。结果显示:肾移植后近曲小管上皮细胞的DR抗原表达增加,肾小球的DR抗原表达减少;急、慢性排导反应,急性肾小管坏死时,肾小管及肾间质的DR抗原表达均明显增加;环孢素中毒时,肾单位的DR抗原表达正常,肾间质的DR抗原表达增加。肾脏HLA-DR抗原表达在肾移植后的变化,对于排异反应的诊断、鉴别诊断、判断预后及治疗决策具有重要意义。
Immuno-enzyme-linked immunosorbent assay was used to detect HLA-DR antigen in 95 cases of renal biopsy specimens of 47 cases of allogeneic kidney transplantation, and to do the research of light microscope, electron microscope, immunopathological examination and lymphocyte subsets. The results showed that the expression of DR antigen in proximal tubule epithelial cells increased and the expression of DR antigen in glomeruli increased after renal transplantation. The expression of DR antigen in renal tubules and renal interstitium in acute and chronic renal tubular necrosis Significantly increased; cyclosporine poisoning, nephron expression of normal DR antigen, renal interstitial DR antigen expression increased. Renal HLA-DR antigen expression changes after kidney transplantation for rejection diagnosis, differential diagnosis, prognosis and treatment decisions of great significance.