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目的评价广东省乙型肝炎(乙肝)疫苗(HepB)纳入儿童免疫规划后的工作质量和效果。方法对常规免疫接种率报告系统中HepB3接种和HepB1及时接种情况进行分析;采用两阶段按容量比例概率抽样方法随机调查3 578名儿童HepB接种情况;开展3岁以下儿童乙肝病毒感染相关标志的血清学监测。结果HepB3报告接种率>95%,儿童建证率99.05%,建卡率97.32%,HepB3调查接种率为93.07%,HepB1及时接种率为75.01%。3岁以下儿童HBsAg携带率为0.84%,HepB免疫后乙肝病毒抗体阳转率为93.44%。结论HepB纳入儿童免疫规划后实施良好,新生儿HepB免疫获得预期的免疫效果,但也存在部分地区HepB1及时接种率偏低的问题。提示今后工作重点是提高HepB1及时接种率,尤其是在经济不发达地区。
Objective To evaluate the quality and effectiveness of Hepatitis B vaccine (Hepatitis B) vaccine in Guangdong Province after its inclusion in childhood immunization program. Methods HepB3 inoculation and timely inoculation of HepB1 in routine immunization coverage rate reporting system were analyzed. HepB inoculation of 3 578 children was investigated randomly by two-stage sampling method with volume-proportion probability. A serum of hepatitis B virus infection-related markers Learning to monitor. Results The inoculation rate of HepB3 was 95%, the rate of establishing children ’s certificate was 99.05%, the rate of establishing card was 97.32%, the vaccination rate of HepB3 was 93.07%, and the timely vaccination rate of HepB1 was 75.01%. HBsAg carrier rate in children under 3 years of age was 0.84%, hepatitis B virus antibody positive rate of HepB immunization was 93.44%. Conclusion After HepB was incorporated into childhood immunization program, HepB immunization achieved the expected immune effect, but there was also a problem that HepB1 timely vaccination rate was low in some areas. It is suggested that the focus of work in the future is to increase the timely vaccination rate of HepB1, especially in economically underdeveloped areas.