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作者研究血清血管紧张素转化酶(serum angiotensin-converting enzyme,SACE)与甲状腺疾病及其功能的关系,指出甲状腺激素可能影响SACE的生物合成,这是甲状腺功能亢进(甲亢)病人SACE水平改变的一个潜在原因。作者用荧光测定法测定12例甲亢病人、58名健康对照者及6名甲状腺功能正常对照者的SACE。结果 12例甲亢病人SACE升高(72±31/nmol/min/ml),与58名健康对照者(32.2±10)及6名功能正常的对照者(36±14)相比,差异显著(P<0.001,P<0.005)。3例甲状腺功能减退(甲减)者SACE值为38±3,1例甲状腺炎为26,与正常对照者相比差异不显著。SACE与血清甲状腺素浓度(r=0.60,P<0.01)及T_3树脂吸收(r=0.56,P<0.01)呈显著正相关。讨论 SACE在甲亢病人倾向于升高,但在甲减或可能甲状腺炎病例其变化不超过正常范围。SACE升高与循环甲状腺激素的升高关系特别显著。作者认为,SACE升高的机制可能是,甲状腺素浓度的增
The authors investigated the relationship between serum angiotensin-converting enzyme (SACE) and thyroid disease and their function, pointing out that thyroid hormones may affect the biosynthesis of SACE, a change in the level of SACE in patients with hyperthyroidism Potential reasons. The authors used fluorometry determination of 12 cases of hyperthyroidism patients, 58 healthy controls and six thyroid function control subjects SACE. Results Compared with 58 healthy controls (32.2 ± 10) and 6 healthy controls (36 ± 14), the SACE of 12 patients with hyperthyroidism was significantly higher (72 ± 31 / nmol / min / P <0.001, P <0.005). Three cases of hypothyroidism (hypothyroidism) SACE was 38 ± 3, 1 case of thyroiditis was 26, compared with the normal control group was no significant difference. SACE was positively correlated with serum thyroxine concentration (r = 0.60, P <0.01) and T 3 resin absorption (r = 0.56, P <0.01). Discussion SACE tends to increase in patients with hyperthyroidism, but it does not vary more than the normal range in cases of hypothyroidism or possible thyroiditis. SACE and elevated circulating thyroid hormone is particularly significant relationship. The authors believe that the mechanism of increased SACE may be, thyroid hormone concentration increased