目的:比较七氟烷麻醉与传统氯胺酮麻醉方法在小儿斜疝手术麻醉中的效果和安全性.方法:选择236例择期行斜疝手术的患儿,采用随机数字表法分为七氟烷组和氯胺酮组,记录呼吸、心率及血流动力学相关指标和不良反应发生情况.结果:七氟烷组患儿的平均诱导时间短于氯胺酮组(P＜0.05);七氟烷组患儿的平均苏醒时间短于氯胺酮组;在麻醉前5 min(T1),两组患儿间血流动力学指标HR、SBP、DBP、Sp02以及RR比较差异无统计学意义(P＞0.05);在麻醉后5 min(T2),氯胺酮组患儿的HR、SBP、DBP和RR水平均高于七氟烷组(P＜0.05);在手术完毕后5 min(T3),两组患儿间血流动力学指标HR、SBP、DBP、SpO2、RR比较差异无统计学意义(P＞0.05).在T1、T2和T3时,七氟烷组患儿的血流动力学指标HR、SBP、DBP、SpO2、RR比较差异无统计学意义(P＞0.05);而氯胺酮组患儿在T2时期,HR、SBP、DBP、RR与麻醉前T1和手术完毕后T3时比较差异有统计学意义(P＜0.05).七氟烷组的不良反应总体发生率比氯胺酮组低,差异有统计学意义(P＜0.05).结论:七氟烷在斜疝手术全身麻醉中具有较好的有效性、安全性和较高的苏醒质量.“,”Objective:To compare the effect and safety of sevoflurane and traditional ketamine anesthesia method in pediatric hernia surgery.Methods:Two hundred thirty-six children who would accept pediatric hernia surgery were collected through a table of random numbers for random grouping.The subjects were divided into sevoflurane group and ketamine group.The respiratory frequency (RR),heart rate (HR),the hemodynamic indexes and adverse reactions were recorded.Results:Average induction time of sevoflurane group was significantly shorter than ketamine group (P＜0.05),the average awaken time of sevoflurane group was significantly shorter than ketamine group (P ＜0.05).Five minutes before anesthesia (T1),hemodynamic parameters between two groups with HR,SBP,DBP,SpO2 and RR had no statistical differences (P＞0.05).Five minutes after anesthesia (T2),HR,SBP,DBP and RR of ketamine group were higher than those in sevoflurane group,the differences were statistically significant (P ＜0.05).Five minutes after the surgery (T3),HR,SBP,DBP,SpO2 and RR had no statistical differences between two groups had no statistical differences (P＞0.05).HR,SBP,DBP and RR in ketamine group at T2 were higher than those at T1 and T3(P＜0.05).The overall incidence of adverse reactions of sevoflurane group was lower than ketamine group (P ＜ 0.05).Conclusion:Sevoflurane is an ideal anesthesia method with high efficiency,safety and better recovery quality.