论文部分内容阅读
目的探讨妊高症(PIH)患者血清胱抑素C(CysC)的变化及其对诊断PIH患者早期肾损伤的临床意义。方法对轻、中、重PIH患者共67例和正常晚期妊娠孕妇45例分别检测血清CysC,尿素氮(BUN)和肌酐(Crea),并进行分析比较。结果 PIH患者轻、中、重各组与正常晚期妊娠孕妇组比较,血清CysC的浓度明显升高(P<0.05),且随着病情加重,CysC也显著增加。而血BUN,血Crea的浓度与正常对照组比较无明显差异(P>0.05)。结论血清CysC可在肾轻微损伤时升高,较血BUN,血Crea更敏感,安全。对各阶段PIH患者均有较好的早期肾损伤诊断价值。
Objective To investigate the changes of serum cystatin C (CysC) in patients with pregnancy induced hypertension (PIH) and its clinical significance in the diagnosis of early renal injury in patients with PIH. Methods Serum CysC, BUN and Crea were detected in 67 cases of mild, moderate and severe PIH patients and 45 cases of normal pregnant women of late pregnancy respectively. Results The levels of CysC in serum of patients with mild, moderate and severe PIH were significantly higher than those of normal pregnant women (P <0.05), and the level of CysC was significantly increased with the progression of PIH. Blood BUN, blood Crea concentrations compared with the normal control group no significant difference (P> 0.05). Conclusions Serum CysC can be increased when mild renal damage, more sensitive than blood BUN and blood Crea, and safe. PIH patients in all stages have a good early diagnosis of renal damage.