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目的探讨钩端螺旋体病神经系统后发损害的临床特征、病因、发病机理。方法对来自钩体病疫区并经血清钩体显凝试验证实的109例钩体病神经后发损害患者的临床资料进行分析。结果钩体病神经系统后发损害多见于儿童和青壮年，主要由钩体波摩拿型和黄疸出血型感染引起，在109例中有95例为钩体性脑动脉炎，10例为钩体性多发性神经根炎，3例为钩体性脊髓炎，1例为钩体性脑膜脑炎伴周围动脉炎。采用青霉素、甲硝哒唑、激素等治疗有较好的疗效。结论对来自钩体病疫区儿童和青壮年出现脑血管、周围神经和脊髓损害症状应重视钩体病神经系统后发损害的诊断。
Objective To investigate the clinical characteristics, etiology and pathogenesis of the nervous system after leptospirosis. Methods The clinical data of 109 patients with leptospirosis after neuropathic injury confirmed by the test of leptospiral coagulation were analyzed. Results The leptospirosis neurological system damage more common in children and young adults, mainly by the hook body Bomona type and jaundice bleeding caused by infection, in 109 cases of 95 cases of hook body cerebral arteritis, 10 cases of hook Congenital multiple nerve root inflammation, 3 cases of hook myelitis, 1 case of hook meningoencephalitis with peripheral arteritis. The use of penicillin, metronidazole, hormones and other treatment have a good effect. Conclusions The diagnosis of cerebrovascular, peripheral nerve and spinal cord injury in children and young adults from leptospirosis should be emphasized in the diagnosis of post-nodal damage in the nervous system of leptospirosis.