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以往的实验表明,炎症部位产生的IL-6可以像多肽激素那样引起全身性的变化,如发热、合成急性期蛋白等;患Castleman氏疾病的患者血清中IL-6水平升高,已知此病患者血清中的IL-6主要是由受感染的淋巴结合成的;此外,IL-6血清清除动力学呈双相性,表明某种物质可阻止IL-6的代谢,
Previous experiments have shown that the production of IL-6 at the site of inflammation can cause systemic changes like polypeptide hormones, such as fever and synthesis of acute phase proteins; serum levels of IL-6 in patients with Castleman’s disease are elevated IL-6 in sera from patients is mainly composed of infected lymph nodes. In addition, IL-6 serum clearance kinetics is biphasic, indicating that certain substances can prevent the metabolism of IL-6,