目的探讨二甲双胍治疗多囊卵巢综合征患者的临床疗效。方法选取2013年8月至2016年6月韶关市第一人民医院收治的多囊卵巢综合征患者72例,按随机数字表法分为观察组(41例)和对照组(31例)为研究对象,两组患者均给予炔雌醇环丙孕酮片治疗,观察组患者加用二甲双胍治疗,比较两组患者的治疗总有效率、治疗前后高密度脂蛋白(HDL)、三酰甘油(TG)、总胆固醇(TC)、雌二醇(E2)、促卵泡素(FSH)、黄体生成素(LH)、睾酮(T)、胰岛素抵抗指数(HOMA-IR)水平及不良反应发生情况。结果观察组患者的治疗总有效率高于对照组,差异有统计学意义(P<0.05);观察组患者治疗后HDL高于对照组,TG、TC低于对照组,差异均有统计学意义(均P<0.05);观察组患者治疗后E2高于对照组,FSH、LH、T、HOMA-IR低于对照组,差异均有统计学意义(均P<0.05);两组患者治疗周期内均未发生明显不良反应。结论二甲双胍治疗多囊卵巢综合征可改善患者机体血脂异常代谢情况和内分泌紊乱状态,具有较高的可行性和实用性。 Objective To investigate the clinical efficacy of metformin in the treatment of patients with polycystic ovary syndrome. Methods Seventy-two patients with polycystic ovary syndrome who were admitted to First People’s Hospital of Shaoguan from August 2013 to June 2016 were randomly divided into observation group (41 cases) and control group (31 cases) Subjects, two groups of patients were given ethinylestradiol cyproterone tablets treatment, the observation group plus metformin treatment, the two groups were compared the total effective rate of treatment, before and after treatment of high-density lipoprotein (HDL), triglyceride (TG , Total cholesterol (TC), estradiol (E2), follicle stimulating hormone (FSH), luteinizing hormone (LH), testosterone (T), insulin resistance index (HOMA-IR) and incidence of adverse reactions. Results The total effective rate of observation group was higher than that of control group, the difference was statistically significant (P <0.05). HDL of observation group was higher than that of control group, but TG and TC were lower than that of control group (All P <0.05). The E2 in the observation group was higher than that in the control group, the levels of FSH, LH, T and HOMA-IR in the observation group were lower than those in the control group (all P <0.05) No significant adverse reactions occurred within. Conclusion Metformin treatment of polycystic ovary syndrome can improve the dyslipidemia and endocrine disorders in patients with high availability and practicability.