论文部分内容阅读
目的进一步评价三苯双脒肠溶片治疗钩虫和蛔虫感染者的疗效和安全性。方法用改良加藤厚涂片法(Ka-to-Katz法),对4 70岁的合江县望龙镇居民进行粪便检查,计数钩虫卵和蛔虫卵,定性检查其他蠕虫卵,对部分钩虫感染者采用钩蚴培养法进行虫种鉴定;对14岁以上者,单纯蛔虫感染顿服三苯双脒肠溶片300 mg;单纯钩虫感染顿服400mg;钩虫或蛔虫合并其他肠道蠕虫感染者顿服400 mg;4 14岁儿童感染者顿服三苯双脒肠溶片200 mg,观察服药后的不良反应;治后3 4周采用改良加藤厚涂片法和饱和盐水漂浮法进行1送3检复查,评价治疗效果。结果钩虫感染者的治愈率和有效率分别为87.96%(504/573)和98.95%(567/573);蛔虫感染者的治愈率和有效率分别为97.16%(342/352)和99.71%(351/252);鞭虫感染者的治愈率为81.11%(73/90);不良反应发生率为2.56%(18/704),以头晕、腹痛、乏力为主,药物对受治者血象和肝、肾功能、心电图均无明显影响。结论三苯双脒肠溶片治疗钩虫、蛔虫、鞭虫感染的效果好,副作用少而轻微,有较好的推广应用前景。
Objective To evaluate the efficacy and safety of tribendimidine enteric-coated tablets in the treatment of hookworm and roundworm infections. Methods The Ka-to-Katz method was used to examine the feces of residents in Wanglong Town, Hejiang County, 4 70 years old. The hookworm eggs and roundworm eggs were counted and other worm eggs were qualitatively examined. Infected by the method of identification of species of larvae metamycosis; To over 14 years old, simple Ascaris infection Dayton tribendamidine enteric-coated tablets 300 mg; hookworm infection Dayton 400mg; hookworm or roundworm infection with other intestinal worms Dayton clothing 400 mg; 4 14-year-old children Dayton clothing with tribendimidine enteric-coated tablets 200 mg, observed after taking the adverse reactions; 34 weeks after treatment with modified Kato thick smear method and saturated brine float method 1 3 check to evaluate the treatment effect. Results The cure rate and effective rate of hookworm infection were 87.96% (504/573) and 98.95% (567/573) respectively. The cure rate and effective rate of Ascaris infection were 97.16% (342/352) and 99.71% 351/252). The cure rate of whipworm infected persons was 81.11% (73/90). The incidence of adverse reactions was 2.56% (18/704). The main symptoms were dizziness, abdominal pain and fatigue. Liver, kidney function, ECG had no significant effect. Conclusion Treating hookworm, roundworm, whipworm infection with tribendimidine enteric-coated tablets has good effect, few side effects and slight, and has a good promotion and application prospects.