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随着促性腺激素释放激素(GnRH)脉冲性质的发现,对于诱发排卵可发展成为一种安全的且更近似生理的药物。本文总结了作者对下丘脑性闭经(HA)和多囊卵巢疾病(PCOD)病人皮下应用脉冲GnRH的经验,指出皮下(SC)脉冲GnRH对于HA是有效的,对PCOD相对无效。本研究受试者均为需诱发排卵的不孕病人,年龄26～34岁(平均30.5岁),均进行了完全的不孕评价,除了输卵管闭塞未尽力除外其他不孕因素。10例妇女为HA,至少闭经1年,激素基线值研究
With the discovery of the pulsatile nature of gonadotropin-releasing hormone (GnRH), evasion of ovulation can develop into a safer and more physiologic drug. This article summarizes the experience of subcutaneous pulsed GnRH in patients with hypothalamic amenorrhea (HA) and polycystic ovary disease (PCOD) and points out that subcutaneous (SC) pulsed GnRH is effective for HA and relatively ineffective for PCOD. The subjects were infertile patients who needed to induce ovulation, aged 26 to 34 years old (mean 30.5 years). All patients were evaluated for complete infertility, except infertility factors other than tubal occlusion. Ten women were women with HA, at least 1 year of amenorrhea, and baseline hormone values