目的:分析垂体柄阻断综合征的相关病因,以期减少该病的发生和早期诊治。方法:将53例诊断为垂体柄阻断综合征患者作为病变组,37例相同年龄组正常人作为对照组,搜集相关孕产史及既往史。采用多变量Logistic回归分析垂体柄阻断综合征的相关病因。结果:多因素回归模型分析与垂体柄阻断综合征相关的7种病因,分别为胎位异常(OR=12.107)、新生儿窒息(OR=11.224)、孕期异常(OR=9.204)、生产环境(OR=9.161)、产次(OR=7.195)、胎龄(OR=4.439)、既往史(OR=3.763)。结论:胎位异常、新生儿窒息、孕期异常是垂体柄阻断综合征的主要危险因素。多次生产、生产环境及胎龄因素与垂体柄阻断综合征次相关。既往史与垂体柄阻断综合征无相关。 Objective: To analyze the related etiology of pituitary stalk block syndrome in order to reduce the occurrence and early diagnosis and treatment of the disease. Methods: 53 cases diagnosed as pituitary stalk obstruction syndrome as the lesion group and 37 normal subjects of the same age group as the control group, collecting related maternal history and past history. Multivariate logistic regression analysis of pituitary stalk obstruction syndrome-related etiology. Results: The multivariate regression model was used to analyze the seven causes of pituitary stalk obstruction syndrome (OR = 12.107), neonatal asphyxia (OR = 11.224), abnormal pregnancy (OR = 9.204) OR = 9.161), parity (OR = 7.195), gestational age (OR = 4.439) and past history (OR = 3.763). Conclusion: Abnormal fetal position, neonatal asphyxia and abnormal pregnancy are the main risk factors of pituitary stalk obstruction syndrome. Multiple production, production environment and gestational age factors associated with pituitary stalk obstruction syndrome. Past history and pituitary stalk obstruction syndrome no correlation.