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目的探讨脑梗死患者血浆一氧化氮(NO)水平的变化。方法37例脑梗死患者(病例组),男25例,女12例,年龄(62.3±11.4)岁,接受头颅CT和双侧颈部血管超声检查。根据颈动脉内膜中层厚度(IMT)分为内膜增厚组(1.0mm1.2mm)23例。于发病急性期(3d内)和恢复期(2周)清晨空腹采静脉血,用硝酸还原酶法测定N0-2/N0-3,间接反映一氧化氮的含量。选取同期来门诊接受健康查体的性别、年龄匹配者20例作为对照组。结果脑梗死急性期血NO水平为(42.89±7.75)μmol/L,显著低于对照组[(70.85±7.56)μmol/L,P<0.05];恢复期上升至(57.09±8.26)μmol/L,仍显著低于对照组(P<0.05)。斑块形成组的血NO水平急性期为(39.31±6.74)μmol/L,显著低于内膜增厚组[(48.78±5.40)μmol/L,P<0.05);恢复期为(53.71±6.95)μmol/L,仍显著低于内膜增厚组[(62.63±7.36)μmol/L,P<0.05]。结论脑梗死患者血浆NO水平下降。颈动脉硬化程度越重,NO水平越低。NO水平下降可能与脑梗死的发生发展相关。NO可作为动脉粥样硬化严重程度的参考指标。
Objective To investigate the changes of plasma nitric oxide (NO) levels in patients with cerebral infarction. Methods Thirty-seven patients with cerebral infarction (case group), 25 males and 12 females, aged 62.3 ± 11.4 years old underwent cranial CT and bilateral neck vascular ultrasonography. According to carotid intima-media thickness (IMT), there were 14 cases with IMT (1.0mm 1.2mm). Fasting venous blood was collected in the early morning during the acute phase (3d) and recovery (2 weeks), and N0-2 / N0-3 was measured by nitrate reductase method, which indirectly reflected the content of nitric oxide. Select the same period outpatient acceptance of physical examination of gender, age matched 20 cases as a control group. Results The level of blood NO in the acute stage of cerebral infarction was (42.89 ± 7.75) μmol / L, which was significantly lower than that in the control group [(70.85 ± 7.56) μmol / L, P <0.05] , Still significantly lower than the control group (P <0.05). The level of blood NO in plaque-forming group was (39.31 ± 6.74) μmol / L acutely, which was significantly lower than that in intimal thickening group [(48.78 ± 5.40) μmol / L, P <0.05) ) μmol / L, still significantly lower than intimal thickening group [(62.63 ± 7.36) μmol / L, P <0.05]. Conclusion Plasma NO levels decline in patients with cerebral infarction. The more severe carotid atherosclerosis, the lower the level of NO. Decreased NO levels may be related to the occurrence and development of cerebral infarction. NO can be used as a reference for the severity of atherosclerosis.