【作用特点】本品为外周神经元和中枢神经系统内5羟色胺第3类(5HT_3)受体的高效、高选择性的拮抗剂。某些药物,特别是抗癌药物可激发胃肠道粘膜释出5HT_3,诱导呕吐反射,造成呕吐。本品选择性阻断这一反射中外周神经元的突触前5HT_3受体的兴奋,并且可能在中枢神经系统内对5HT_3受体转递的迷走神经传入后区的作用有直接影响。 【Features】 This product is the peripheral neurons and central nervous system serotonin type 3 (5HT_3) receptor of the highly efficient, highly selective antagonist. Some drugs, especially anti-cancer drugs can stimulate gastrointestinal mucosal release 5HT_3, induced vomiting reflex, causing vomiting. This product selectively blocks the excitability of this pre-synaptic 5HT 3 receptor, which reflects the mid-peripheral neurons, and may have a direct effect on the afferent area of ​​the vagal afferent nerve transmitted by the 5HT 3 receptor in the central nervous system.