目的探讨颅神经损伤程度分级与鼻咽癌患者预后的关系。方法收集2005年1月至2009年12月广州医科大学附属肿瘤医院初治伴颅神经损伤鼻咽癌患者165例,分析颅神经损伤程度与鼻咽癌远期生存的关系及其对T分期的影响。结果 165例颅神经损伤患者中,单支颅神经受损患者68例,多支颅神经同时受损患者97例,68例单支颅神经损伤患者中以外展神经损伤最为常见,发生率为47.1%(32/68)。生存率的计算采用Kaplan-Meier法,单支颅神经损伤患者5年总生存率为69.8%,多支颅神经损伤患者5年总生存率为54.3%,通过log-rank法进行生存率的显著性检验,两组差异有统计学意义(P=0.033)。结论鼻咽癌患者颅神经损伤数目与预后显著相关。在鼻咽癌T分期中对颅神经损伤进行适当的程度分级有进一步研究的必要。 Objective To investigate the relationship between the degree of cranial nerve injury and the prognosis of patients with nasopharyngeal carcinoma. Methods A total of 165 nasopharyngeal carcinoma patients with cranial nerve injury were collected from the Affiliated Tumor Hospital of Guangzhou Medical University from January 2005 to December 2009 to analyze the relationship between the degree of cranial nerve injury and the long-term survival of nasopharyngeal carcinoma and its relationship with T stage influences. Results Among the 165 patients with cranial nerve injury, 68 patients with single cranial nerve injury, 97 patients with multiple cranial nerve injuries at the same time, and 68 patients with single craniocerebral injury had the most common nerve injury, the incidence rate was 47.1 % (32/68). Survival rate was calculated using Kaplan-Meier method. The 5-year overall survival rate was 69.8% in patients with single craniocerebral injury and 54.3% in patients with multiple cranial nerve injury. The survival rate was significantly higher by log-rank Sex test, the difference between the two groups was statistically significant (P = 0.033). Conclusion The number of cranial nerves in nasopharyngeal carcinoma is significantly correlated with prognosis. In the T stage of nasopharyngeal carcinoma of the cranial nerve injury in the appropriate degree of grading necessary further study.