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目的探讨血清降钙素原(PCT)、C反应蛋白(CRP)在恶性肿瘤患者导管相关血液感染中的应用价值。方法对120例患恶性肿瘤因化疗需置管的患者,分别检测其血液中PCT、CRP的水平,并进行统计分析。结果导管感染组患者的血清PCT、CRP水平明显高于未感染组(P<0.05),两组中差异有统计学意义;血清PCT、CRP在发生导管相关感染时呈正相关(r=0.87,P<0.05),且导管留置时间越长,其发生导管相关感染的机率越大。结论血清PCT、CRP在发生导管相关感染时呈正相关,均在患者早期血液中明显升高,经抗感染治疗后降低显著。动态测定血清PCT、CRP对肿瘤患者感染的发生尤其是细菌感染性疾病早期判断的特异性具有重要价值,对于临床导管相关感染,可连续检测PCT、CRP水平指导临床用药。
Objective To investigate the value of serum procalcitonin (PCT) and C-reactive protein (CRP) in the treatment of catheter-related bloodstream infections in patients with malignant tumors. Methods The levels of PCT and CRP in blood of 120 patients with malignant tumors requiring catheterization for chemotherapy were determined and statistically analyzed. Results The serum PCT and CRP levels in patients with catheter infection were significantly higher than those in non-infected patients (P <0.05), and there was a significant difference between the two groups. Serum PCT and CRP were positively correlated with catheter-related infection (r = 0.87, P <0.05), and catheter indwelling time is longer, the greater the probability of catheter-related infection. Conclusions Serum PCT and CRP were positively correlated with catheter-related infection, both of which were significantly increased in the early stage of patients’ blood and significantly decreased after anti-infective treatment. The dynamic determination of serum PCT and CRP is of great value in the early diagnosis of the infection of tumor patients, especially the bacterial infectious disease. For clinical catheter-related infections, the levels of PCT and CRP can be continuously monitored to guide the clinical medication.