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目的 :探讨 β受体阻滞剂比索洛尔对冠心病患者的QT离散度 (QTd)及其相关指标的影响。方法 :将 2 45例冠心病中无并发症者随机分为对照组和试验组 ,前者进行常规治疗 ,后者加入比索洛尔治疗 ;样本中合并心律失常、心力衰竭者 ,先处理并发症 ,再加入比索洛尔干预。观察HR、QTmin、QTmax、QT、QTd、JT、JTd变化。微机数理统计。结果 :对照组上述指标均无明显变化(P >0 0 5 ) ,试验组QTd、JT、JTd等指标显著缩小 (P <0 0 5 )。单纯纠正心力衰竭、抗心律失常对其QTd、JT和JTd等指标无显著改变 ( P >0 0 5 ) ;二者纠正后再加用比索洛尔 ,QTd等显著缩小 ( P <0 0 5 )。结论 :单纯抗心肌缺血、抗心律失常、抗心力衰竭不能改善冠心病患者心肌电生理 ,而 β受体阻滞剂可有效地缩小心肌复极化离散程度而降低冠心病猝死率
Objective: To investigate the effect of β-blocker bisoprolol on QTd and its related indexes in patients with coronary heart disease. Methods: Two hundred and seventy-five cases of coronary heart disease without complications were randomly divided into control group and experimental group, the former for conventional treatment, which was added bisoprolol treatment; sample with arrhythmia, heart failure, the first treatment of complications, Then add bisoprolol intervention. The changes of HR, QTmin, QTmax, QT, QTd, JT and JTd were observed. Computer mathematical statistics. Results: There was no significant difference between the control group and the control group (P> 0.05). The indexes of QTd, JT and JTd in the experimental group were significantly reduced (P <0.05). Correction of heart failure and antiarrhythmia had no significant change on QTd, JT and JTd (P> 0.05), but both of them were significantly reduced after treatment with bisoprolol and QTd (P <0.05) . Conclusion: Anti-myocardial ischemia alone, anti-arrhythmia, anti-heart failure can not improve myocardial electrophysiology in patients with coronary heart disease, and β-blockers can effectively reduce the myocardial repolarization dispersion and reduce the rate of sudden death in patients with coronary heart disease