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以整群随机抽样方法对广西２市４县的１～６０岁自然人群２０８４人进行了甲乙丙戊４型肝炎病毒重叠感染的血清学研究。结果两型以上肝炎病毒重叠感染率在人群中为６４．２％，占感染者的７０．３％，各地区变动在４７．７％～８０．６％之间，其变化与感染率变化一致，并随年龄而逐步上升。重叠感染者中，二、三、四型重叠感染分别占７５．７％、２３．０％和１．３％，最早年龄分别在１、２、６岁。重叠感染组合有１１种，以ＨＡＶ与ＨＢＶ二重感染最常见（６５．７％）和出现最早（１岁），三重感染中以ＨＡＶ、ＨＢＶ、ＨＥＶ重叠多见和出现最早（２岁）。既往有病毒性肝炎病史者的重叠感染率（７８．８％）高于无既往肝炎病史者（６３．６％）（Ｐ＜０．０１）。结果提示，甲、乙、丙、戊型肝炎病毒的重叠感染广泛存在于广西自然人群中，而且开始于生命早期
A total of 2,084 people from 1 to 60 years old in 4 cities in 2 cities of Guangxi were enrolled in this study. Serological studies on the overlap infection of hepatitis B, B hepatitis E virus were performed. Results The prevalence of over-infection of hepatitis B virus was 64.2% among the population, accounting for 70.3% of the infected population, with 47.7% to 80.6% changing in all regions. The change was consistent with the change of infection rate , And gradually increase with age. Overlapping infections, two, three, four overlapping infections accounted for 75.7%, 23.0% and 1.3%, the earliest age were 1, 2, 6 years old. There were 11 kinds of overlapping infection combinations. HAV and HBV were the most common (65.7%) and the earliest (1 year old) with triple infection of HAV and HBV. HAV, HBV and HEV were more common and appeared the earliest (2 years old) in triple infection. Previously, patients with a history of viral hepatitis had a higher prevalence of infection (78.8%) than those without previous history of hepatitis (63.6%) (P <0.01). The results suggest that over-infection of A, B, C and E viruses is widely found in natural populations of Guangxi and started early in life