扁平苔藓(LP)是一种较常见的疾病,皮肤损害合并粘膜损害约占50％,仅有粘膜损害的约占15％。过去对口腔扁平苔藓(OLP)的治疗都不满意。近十年来,应用免疫组化和电镜等研究提示LP可能是对表皮基底层的一种细胞介导的自身免疫性疾病,因此有用免疫抑制剂治疗LP的报道,但结果尚不一致。为此,作者设计了一项随机、对照及前瞻性研究,以探讨环孢素A(CyA)外用治疗OLP的疗效。 方法:13例OLP患者,均由病理确诊。病 Lichen planus (LP) is a common disease that causes mucosal damage in about 50% of skin lesions and only about 15% of mucosal lesions. In the past the treatment of oral lichen planus (OLP) are not satisfied. In the recent ten years, the use of immunohistochemistry and electron microscopy prompted LP may be a cell-mediated autoimmune disease of the basal layer of the epidermis, therefore, the use of immunosuppressive agents for the treatment of LP, but the results are not consistent. To this end, the authors designed a randomized, controlled and prospective study to investigate the efficacy of topical cyclosporin A (CyA) in the treatment of OLP. Methods: Thirteen OLP patients were diagnosed by pathology. disease