论文部分内容阅读
目的 探讨凝血 -纤溶系统变化在妊高征凝血障碍机制中的作用 ,为妊高征诱发DIC的预测提供有效诊断方法。方法 选择非孕组 40例 ,妊娠组 12 0例 ,妊高征组 5 0例 ,妊高征产后组 2 6例。采用双抗夹心酶联免疫吸附法 (ELISA)检测血浆凝血酶 -抗凝血酶复合物 (TAT)、D -二聚体 (D_dimer)含量 结果 (1)正常早、中、晚孕TAT水平 ,与非孕组比较 ,差异有显著性 (P <0 0 5 ) ;中、重度妊高征组分别为 (15 4± 2 8) μg/L、 (2 0 5± 6 2 ) μg/L ,与晚孕组比较 ,差异有非常显著性 (P <0 0 1)。 (2 )正常早、中、晚孕D_dimer水平与非孕组比较 ,差异有非常显著性(P <0 0 1) ;中、重度妊高征组分别为 (1616 5± 14 8 1) μg/L、 (3 863 7± 3 42 4) μg/L ,与晚孕组比较 ,差异有非常显著性 (P <0 0 1) ;妊高征产后中、重度组较晚孕组明显增高 (P <0 0 5 )。结论 妊娠中晚期动态监测血浆TAT、D_dimer含量可做为DIC前状态敏感有效的辅助诊断。
Objective To investigate the role of coagulation-fibrinolysis system in the mechanism of coagulation disorders in PIH and to provide an effective diagnostic method for the prediction of DIC induced by PIH. Methods Forty cases in non-pregnant group, 120 cases in pregnancy group, 50 cases in PIH group and 26 cases in PIH group were selected. The levels of plasma thrombin - antithrombin complex (TAT) and D - dimer were measured by double - antibody sandwich enzyme - linked immunosorbent assay (ELISA) (1) The levels of TAT in normal early, (15 4 ± 2 8) μg / L, (2 0 5 ± 6 2) μg / L, respectively, compared with those in non-pregnant group (P 0 05) Compared with the late pregnancy group, the difference was significant (P <0.01). (2) The levels of D_dimer in normal early, middle and late pregnancy were significantly different from those in non-pregnant group (P <0.01); those in moderate and severe PIH were (1616 5 ± 14 8 1) μg / L and (3 863 7 ± 3 42 4) μg / L, respectively. Compared with the late pregnant group, the difference was significant (P <0.01) <0 0 5). Conclusion Dynamic monitoring of plasma TAT and D_dimer content during the second trimester of pregnancy can be used as a sensitive and effective adjuvant diagnosis for the pre-DIC state.