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目的探讨药物性肝病的病因和临床特点。方法根据患者服药史、临床表现、血象、肝功能、病原学标志以及停药后的效应作出综合判断。结果引起肝病的有关药物中 ,抗结核病药占 2 6 .4 % ,解热镇痛抗炎药占 1 3 .2 % ,降血糖药占 1 1 .3 % ,抗肿瘤类药占9.43 % ,中草药类占 7.55 % ,抗菌药占 7.55 % ,抗真菌药占 5 .66 % ,其它类药共占 30 .1 9%。临床病理分型 :53例中肝细胞损伤型 (包括肝炎型、脂肪肝型 ) 34例 ,胆汁淤积型 7例 ,混合型 1 0例 ,慢性药物性肝病 2例 ,经停药治疗后 ,大部分病例痊愈 ,1例亚急性重型肝炎患者死亡。结论临床医师应重视药物性肝病的预防、诊断和治疗。
Objective To explore the etiology and clinical features of drug-induced liver disease. Methods Based on the history of patients taking medication, clinical manifestations, blood, liver function, etiological markers and the effect after stopping to make a comprehensive judgment. Results Among the drugs that caused liver diseases, anti-tuberculosis drugs accounted for 26.4%, antipyretic and analgesic anti-inflammatory drugs accounted for 13.2%, hypoglycemic drugs accounted for 11.3%, anti-tumor drugs accounted for 9.43% Chinese herbal medicine accounted for 7.55%, 7.55% antibacterial drugs, antifungal drugs accounted for 5.66%, other drugs accounted for 30.19%. Clinicopathological typing: 34 cases of hepatocellular injury (including hepatitis type and fatty liver type), 7 cases of cholestatic type, 10 cases of mixed type and 2 cases of chronic drug-induced liver disease in 53 cases. After stopping treatment, large In some cases, 1 patient died of subacute severe hepatitis. Conclusion Clinicians should pay attention to the prevention, diagnosis and treatment of drug-induced liver disease.