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目的:探讨~(125)I粒子植入近距离放疗联合内分泌治疗老年局部晚期前列腺癌的临床疗效。方法:回顾性分析我院90例老年前列腺癌患者,按治疗方法不同分为观察组以及对照组,每组45例,其中观察组采用~(125)I粒子植入联合内分泌治疗,对照组单纯应用内分泌治疗,对比分析两组患者治疗前后PSA、治疗期、间歇期以及生化无进展生存时间。结果:观察组治疗后12、24、36个月前列腺特异性抗原(PSA)明显低于对照组,差异有统计学意义(P<0.001),观察组的间歇期以及生活无进展生存时间明显长于对照组,差异有统计学意义(P<0.001)。结论:经直肠穿刺~(125)I粒子植入联合内分泌治疗老年局部晚期前列腺癌可以有效延缓疾病的进展,值得临床推广应用。
Objective: To investigate the clinical efficacy of ~ (125) I seed implantation brachytherapy combined with endocrine in the treatment of elderly locally advanced prostate cancer. Methods: A retrospective analysis of 90 cases of elderly patients with prostate cancer in our hospital, according to the different treatment methods were divided into observation group and control group, 45 cases in each group, the observation group using 125I I seed implantation combined with endocrine therapy, the control group simple Application of endocrine therapy, comparative analysis of two groups before and after treatment PSA, treatment, intermittent and biochemical progression-free survival time. Results: The prostate specific antigen (PSA) of observation group was significantly lower than that of control group at 12, 24, and 36 months after treatment (P <0.001), and the intermission period and progression-free survival time of observation group were significantly longer than those of control group The control group, the difference was statistically significant (P <0.001). Conclusion: Rectal puncture ~ (125) I seed implantation combined with endocrine in the treatment of elderly locally advanced prostate cancer can effectively delay the progression of the disease and is worthy of clinical application.