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目的:探讨中期妊娠引产应用米非司酮与米索前列醇联合水囊方法的有效性与安全性。方法:对2007年8月～2010年6月来我院自愿要求终止妊娠的孕12～28周孕妇160例,分别采用A组米非司酮与米索前列醇联合水囊引产方法、B组米非司酮配伍米索前列醇方法及C组利凡诺羊膜腔内注射方法终止妊娠,进行回顾性研究。结果:A组引产成功率高于B组,差异有统计学意义(P<0.05),明显高于C组,A组从首次口服米索前列醇开始至分娩时间明显短于C组(P<0.01),A组与B组比较,差异有统计学意义(P<0.05)。引产成功病例中,产后清宫率A组少于B组(P<0.05),明显少于C组(P<0.01),产后2 h出血量A组与B组比较,差异无统计学意义(P>0.05),明显少于C组(P<0.01)。结论:米非司酮与米索前列醇联合水囊终止中期妊娠具有引产时间短、引产成功率高、胎盘残留少、宫颈裂伤少、副作用少的优点。
Objective: To investigate the efficacy and safety of mifepristone combined with misoprostol in the induction of labor in mid-term pregnancy. Methods: From August 2007 to June 2010, 160 pregnant women of 12 to 28 weeks pregnant who voluntarily demanded termination of pregnancy in our hospital were enrolled. Group A was treated with mifepristone combined with misoprostol in combination with misoprostol, and group B Mifepristone with misoprostol method and group C rivanol amniotic cavity injection termination of pregnancy, a retrospective study. Results: The successful rate of induction of labor in group A was higher than that in group B (P <0.05), which was significantly higher than that in group C (P <0.05). The time from first oral misoprostol to delivery in group A was shorter than that in group C (P < 0.01). There was significant difference between group A and group B (P <0.05). In the successful induction of labor, the rate of postpartum cesarean section in group A was less than that in group B (P <0.05), significantly less than that in group C (P <0.01), and there was no significant difference between group A and group B > 0.05), significantly less than the C group (P <0.01). Conclusion: The combination of mifepristone and misoprostol in termination of mid-term pregnancy has the advantages of short induction time, high success rate of induced labor, less placental residue, fewer cervical lacerations and fewer side effects.