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多项临床与基础研究均表明神经多肽食欲素-A(orexin-A,OXA)可能与神经系统疾病包括缺血性脑病密切相关。最近有体外实验证实外源性OXA可以促进与神经元耐受缺血缺氧密切相关的重要信号分子低氧诱导因子1α(hypoxia-inducible factor-1α,HIF-1α)的表达增加,但OXA在缺血性脑损害中到底发挥何种作用及其机制,目前没有相关的实验研究报道。本研究采用大脑中动脉栓塞模型(middle cerebral artery
A number of clinical and basic studies have shown that the orexin-A orexin-A (OXA) may be closely related to neurological diseases including ischemic encephalopathy. Recently, in vitro experiments showed that exogenous OXA can promote the expression of hypoxia-inducible factor-1α (HIF-1α), an important signaling molecule closely related to neuronal tolerance to hypoxia and hypoxia, What role and mechanism of ischemic brain damage play in the end, there is no relevant experimental study reported. This study used the middle cerebral artery occlusion model