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目的测定３－氧－乙酰－１１－脱氧甘草次酸铝（Ａｌｕｍｉｎｕｍ３－ｏ－ａｃｅｔｙｌ－１１－ｄｅｏｘｏｇｌｙｃｙｒｈ－ａｔｅ，ＡＤＡ）的半数致死量（ＬＤ５０）及对大鼠血清钠、钾浓度的影响。方法昆明小鼠６０只，体重２０±１ｇ，随机分６组，每组１０只，各组按不同剂量的ＡＤＡ０．２ｍｌ·１０ｇ－１灌胃，给药后按急性毒性实验法连续观察７ｄ。Ｗｉｓｔａｒ大鼠４０只，体重２００±１０ｇ，随机分４组，每组１０只。各组分别给０．５％羧甲基纤维素钠（ＣＭＣ）、生胃酮（Ｃａｒｂｅｎｏｘｏｌｏｎｅ，ＣＮ）和两个剂量的ＡＤＡ，早晚灌胃一次，连续１２ｄ后，处死大鼠取血，测血清钠、钾浓度。结果灌胃ＡＤＡ的ＬＤ５０为４４４４±８３１．５ｍｇ·ｋｇ－１。长期用药，ＡＤＡ未引起大鼠血清钠、钾浓度的明显变化，相反ＣＮ却显著降低血清钾浓度。结论ＡＤＡ引起急性致死性中毒的危险性甚小，长期用药未引起大鼠血清钠、钾浓度的变化
Objective To determine the LD50 of sodium 3-oxo-acetyl-11-deoxoglycyrhodate (ADA) and its effect on serum sodium and potassium concentrations in rats. Methods Sixty Kunming mice weighing 20 ± 1g were randomly divided into 6 groups (10 rats in each group). The rats in each group were given intragastric administration of ADA0.2ml · 10g-1 at different dosages. After administration, the mice were continuously observed for 7 days by acute toxicity test. Wistar rats 40, weighing 200 ± 10g, were randomly divided into 4 groups of 10. Rats in each group were given 0.5% sodium carboxymethyl cellulose (CMC), carbenoxolone (CN) and two doses of ADA respectively. After 12 days, Sodium, potassium concentration. Results The LD50 of ADA was 4444 ± 831.5 mg · kg-1. Long-term medication, ADA did not cause significant changes in serum sodium and potassium concentrations, while CN significantly lower serum potassium levels. Conclusions The risk of acute lethal poisoning caused by ADA is very small. Long-term medication does not cause changes of serum sodium and potassium concentration in rats