p21活化激酶(PAKs)是肿瘤细胞内信号网络的关键调节因子之一,其可以通过众多的下游结合蛋白,对肿瘤细胞的生存、伪足形成、细胞周期、细胞侵袭和迁移等众多生物学功能发挥调节作用,因此,目前已成为肿瘤治疗的新靶点。本文对近年来PAKs及其抑制剂研究的最新进展进行综述,以期为新型抗肿瘤药物的研发提供参考依据。 p21-activated kinases (PAKs) are one of the key regulators of signal transduction in tumor cells. They can bind to many biological functions of tumor cells such as survival, pseudopodia formation, cell cycle, cell invasion and migration through numerous downstream binding proteins Play a regulatory role, therefore, has now become a new target for cancer treatment. This review summarizes the recent progress of PAKs and its inhibitors in recent years, with a view to provide a reference for the development of new antitumor drugs.