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天然孕激素是卵巢分泌的性激素。通常临床上应用的是人工合成的孕激素。其一类为17α-羟基孕酮类,如己酸孕酮(Hydroxyprogesterone Caproate)、甲孕酮(Medroxyprogestecone Acetate)、醋酸甲地孕酮(Megestrol Acetate)、氯地孕酮(Chlormadinone)等;另一类为19-去甲睾丸素类,如醋酸炔诺酮(Norethisterone)、18-甲基炔诺酮(Norgestrel)等。关于内源性孕激素的生理调节作用,生物转化过程和临床诊断等方面研究,以及外源性孕激素类药物的药物质量鉴定、药理作用、药物动力学和制剂学等方面工作,均有不少文献报道。而上述这些研究中,孕激素分析检测方法的建立和应用,是其中不
Natural progesterone is a hormone secreted by the ovary. The commonly used clinical application is synthetic progestin. One class is 17α-hydroxyprogesterone, such as Hydroxyprogesterone Caproate, Medroxyprogestecone Acetate, Megestrol Acetate, Chlormadinone and the like; the other The class is 19-nor-testosterone, such as norethisterone, 18-norgestrel and the like. Physiological regulation of endogenous progesterone, bioconversion process and clinical diagnosis, as well as exogenous progesterone drug quality appraisal, pharmacological effects, pharmacokinetics and pharmaceutics and other aspects of work, are not Less literature reports. However, in these studies, the establishment and application of the progestin assay is not