在动脉粥样硬化发生发展过程中,巨噬细胞发挥了重要作用。巨噬细胞泡沫化是动脉粥样硬化发生过程中的一个标志性事件。一旦巨噬细胞脂质稳态动态平衡被打破会引起细胞泡沫化。细胞因子可通过不同途径调控相应的酶或受体表达,以及细胞因子与巨噬细胞的相互作用,从而调控细胞脂质稳态。本文就近年细胞因子与巨噬细胞脂质稳态方面的研究进行综述。 Macrophages play an important role in the development of atherosclerosis. Macrophage foam is a hallmark event in the development of atherosclerosis. Once the homeostasis of macrophage lipid homeostasis is broken, it can cause cell foaming. Cytokines can regulate the lipid homeostasis by regulating the corresponding enzyme or receptor expression and the interaction between cytokines and macrophages. This review summarizes the studies on lipid homeostasis of cytokines and macrophages in recent years.