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癫痫是由成千上万神经元高度同步化异常放电所引起,病变神经元将疾病的痫性信号向相关神经元传递是引起癫痫发作的根本条件。痫性信号在神经元之间的传递是癫痫发生机制的重要环节。常规的突触通道不能满足癫痫发生中的痫性放电信号传递的需要,故即针对痫性信号传递机制中的非常规生理通道包括沉默突触的激活、电突触的活化及突触囊泡的循环进行综述,阐述在癫痫发生时这些非常规生理通道的激活或开放与痫性信号传递机制的关系。了解痫性放电信号传递的机制将可能从根本上为癫痫的防治提供新的思想和方法。
Epilepsy is caused by the abnormally synchronized abnormal discharges of thousands of neurons. The diseased neurons transmit the epileptic signal of the disease to the relevant neurons, which is the fundamental condition that causes seizures. The transmission of epileptic signals between neurons is an important part of the mechanism of epilepsy. Conventional synaptic channels can not meet the need for signal transduction of epileptic seizures in epilepsy. Therefore, unconventional physiological pathways involved in the epileptic signaling mechanism include the activation of silent synapses, activation of electrical synapses and synaptic vesicles The review summarizes the relationship between the activation or opening of these unconventional physiological pathways and the mechanism of epileptic signaling during epilepsy. Understand the mechanism of signal transmission of epileptic discharge will probably provide fundamentally new ideas and methods for the prevention and treatment of epilepsy.