肝脏的首过作用早已被人们所重视。如硝酸甘油从胃肠道吸收后,在肝脏中迅速被谷胱甘肽、有机硝酸脂还原酶所代谢,只有少量或没有活性的成分到达血液循环而起不到治疗作用。为了克服某些首次通过效应,确保药效,常采用的方法如下: 一、口腔给药口腔给药系将舌下片放在舌下或将口腔片置于面颊与齿之间的一 The first role of the liver has long been valued. Such as nitroglycerin absorbed from the gastrointestinal tract, the rapid hepatic glutathione, organic nitrate reductase metabolism, only a small amount or no active ingredients to reach the blood circulation and play a therapeutic role. In order to overcome some of the first time through the effect, to ensure efficacy, often used as follows: First, the oral administration Oral administration of the tongue under the tongue or sublingual tablets placed between the cheeks and teeth