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中草药的推广与应用与其自身的安全性与有效性密切相关。多种中草药与化学药物的临床合用,药物之间会因为相关代谢酶的被诱导或抑制,导致药物代谢以及疗效的改变,并最终引发药物的不良反应。本文追踪了近年来报道的关于中草药与化学药物合用的药物配伍、药物代谢动力学方面的相互作用、机制,以及目前对中草药与化学药物合用的机制研究平台的最新进展。
The promotion and application of Chinese herbal medicine are closely related to its own safety and effectiveness. A variety of Chinese herbal medicine and the clinical use of chemical drugs, the drug will be related to metabolic enzymes are induced or inhibited, leading to drug metabolism and efficacy changes, and eventually lead to adverse drug reactions. This paper traces the recent reports on the interactions and mechanisms of drug compatibility and pharmacokinetics of Chinese herbal medicine with chemical drugs and the current research progress on the mechanism research platform for the combination of Chinese herbal medicine with chemical drugs.