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目的探讨P53、P185蛋白的表达与胆囊癌的发生及生物学行为的关系。方法利用免疫组织化学技术检测P53、P185蛋白在34例胆囊癌和28例慢性胆囊炎中的表达。结果慢性胆囊炎中P53的阳性率为7％，而胆囊癌中为41％．两者差异显著（P＜0.01）。慢性胆囊炎中P185的阳性率为14％，而胆囊癌中为47％，两者差异显著（P＜0．01）。低分化胆囊癌中P53、P185的阳性率分别为66．7％及75％，而高中分化组中分别为27．3％及31％，差异显著（P＜0．05）。结论P53、P185过表达与胆囊癌的发生有密切联系．而且两者可能起协同作用。另外P53、P185的表达与胆囊癌的分化程度有关，但与胆囊癌的浸润或转移关系不明显。
Objective To investigate the relationship between the expression of P53 and P185 protein and the occurrence and biological behavior of gallbladder carcinoma. Methods Immunohistochemistry was used to detect the expression of P53 and P185 proteins in 34 cases of gallbladder carcinoma and 28 cases of chronic cholecystitis. Results The positive rate of P53 in chronic cholecystitis was 7%, while in gallbladder carcinoma it was 41%. The difference between the two was significant (P<0.01). The positive rate of P185 in chronic cholecystitis was 14%, while that in gallbladder cancer was 47%. There was a significant difference between them (P<0.01). The positive rates of P53 and P185 in poorly differentiated gallbladder carcinoma were 66.7% and 75%, respectively, and 27.3% and 31% in the high school differentiation group, respectively (P<0.05). Conclusion Overexpression of P53 and P185 is closely related to the occurrence of gallbladder cancer. And the two may play a synergistic role. In addition, the expression of P53 and P185 was related to the degree of gallbladder carcinoma differentiation, but it was not significantly related to the invasion or metastasis of gallbladder carcinoma.