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目的探讨胎儿唇腭裂发生和干预措施。方法选择2011~2014年在余姚市各接生单位分娩的围产儿及<28w的治疗性引产儿进行监测。结果余姚市4年间共出生50554例,发现唇腭裂90例,总发生率为17.8/万,其中围产儿发生率为9.69/万;唇裂合并腭裂52例、单纯唇裂31例、单纯腭裂7例;有11例合并其他类型的出生缺陷;90例唇腭裂患儿,活产儿40例,死胎3例,治疗性引产47例,<28w治疗性引产41例,≥28w治疗性引产6例;产前诊断率为(54.44%),其中<28w产前诊断41例,≥28w产前诊断8例,产后诊断41例(占45.56%);<28w产前诊断率以唇腭裂最高,为45.56%,其次为唇裂为32.26%,腭裂为0。结论余姚市唇腭裂围产儿发病率控制于全国发生率的1/2。加大健康教育的宣传力度,大力实施出生缺陷干预工程,加强围产儿保健工作质量和三级预防队伍建设,提升唇腭裂产前监测质量,制定多方面的干预措施,降低唇腭裂的发生率。
Objective To investigate the occurrence and intervention of fetal cleft lip and palate. Methods From 2011 to 2014, we selected perinatal infants and <28 weeks of therapeutic induced labor who were delivered by delivery units in Yuyao City. Results A total of 50 554 cases of cleft lip and palate were found in Yuyao City during the four years. The total incidence was 17.8 / million. The incidence of perinatal fetus was 9.69 / million. Cleft lip and cleft palate in 52 cases, cleft lip in 31 cases and cleft palate only in 7 cases. There were 11 cases with other types of birth defects; 90 cases of children with cleft lip and palate, 40 live births, 3 stillbirths, 47 cases of induced abortion, 41 cases of 28 weeks of treatment, 6 cases of ≥28 weeks of induced abortion, The diagnosis rate was (54.44%), including <28w prenatal diagnosis in 41 cases,> 28w prenatal diagnosis in 8 cases, postpartum diagnosis in 41 cases (45.56%); <28w prenatal diagnosis rate was highest in cleft lip and palate, 45.56% Followed by cleft lip was 32.26%, cleft palate was 0. Conclusion The incidence of perinatal cleft lip and palate in Yuyao is controlled at 1/2 of the national incidence. We will step up publicity efforts in health education, vigorously implement the birth defect intervention project, strengthen the quality of perinatal care and the construction of tertiary prevention teams, and enhance the quality of prenatal monitoring of cleft lip and palate, and formulate various interventions to reduce the incidence of cleft lip and palate.