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目的 通过对人脑出血周围组织神经微丝(NF)和胶质纤维酸性蛋白(GFAP)计数与计量观察,研究其病理发展过程。方法用58例脑出血解剖标本,在血肿周围多方位自血肿壁向外连续取材1.0-2.0cm。采取免疫组化方法观察NF和GFAP的变化。结果NF损伤程度在血肿周围、双侧皮层、双侧海马区随血肿形成时间延长而加重;GFAP染色强度随血肿形成时间延长而减弱。结论 血肿周围神经元和星形胶质细胞的细胞骨架损伤在脑出血后1周内进行性加重。
Objective To study the pathological development of neurofilament (NF) and glial fibrillary acidic protein (GFAP) in peripheral cerebral hemorrhage. Methods 58 cases of cerebral hemorrhage anatomical specimens in the hematoma around the wall from the hematoma continuous drawing 1.0-2.0cm. Immunohistochemistry was used to observe the changes of NF and GFAP. Results The degree of NF was increased around hematoma, bilateral cortex and bilateral hippocampus with the prolongation of hematoma formation. The intensity of GFAP staining decreased with the time of hematoma formation. Conclusion The cytoskeletal injury of neurons and astrocytes in the hematoma progresses within 1 week after intracerebral hemorrhage.