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目的 :了解 2型糖尿病 (DM)患者血浆抵抗素水平和颈动脉内膜中层厚度 (IMT) ,探讨抵抗素、IMT的关系以及两者与胰岛素抵抗的相互关系。方法 :检测 4 8名 2型 DM患者血浆抵抗素、IMT及相关实验参数 ,并与正常对照组进行比较。结果 :1抵抗素、IMT、胰岛素抵抗指数 (IRI) DM组较正常对照组显著增高 (P <0 .0 0 1 ) ;2抵抗素与 FINS呈负相关 (r =- 0 .392 ,P <0 .0 5 ) ;IMT与年龄、IRI显著正相关 (r分别为 0 .5 0 4、0 .5 4 1 ,P <0 .0 0 1 )。结论 :2型 DM患者存在较高的抵抗素水平 ,IMT相对增厚。胰岛素抵抗是 2型 DM并发动脉粥样硬化的主要危险因素
Objective: To investigate the level of plasma resistin and carotid intima-media thickness (IMT) in type 2 diabetic patients and explore the relationship between resistin and IMT as well as their relationship with insulin resistance. Methods: The plasma resistin, IMT and related experimental parameters were detected in 48 type 2 DM patients and compared with the normal control group. Results: 1 resistin, IMT, insulin resistance index (IRI) DM group was significantly higher than the normal control group (P <0.01); 2 resistin and FINS was negatively correlated (r = - 0.392, P < 0. 05). IMT was significantly and positively correlated with age and IRI (r = 0.54,0.541, P <0.001). Conclusion: Type 2 DM patients have higher levels of resistin and IMT relatively thicker. Insulin resistance is a major risk factor for type 2 DM complicated with atherosclerosis