细胞凋亡是机体清除感染、变异及衰老细胞而维持自身生理性状态的主要调节方式之一。Fas是一种跨膜蛋白 ,与相应配体结合后活化靶细胞固有的死亡程序使细胞发生凋亡。研究表明恶性肿瘤的发生与凋亡密切相关 ,可能是因为正常生理条件细胞凋亡过程被抑制 ,引起细胞数正动态平衡失调所致。目前 ,诱发细胞凋亡已成为肿瘤治疗的新思路 ,并且已取得了初步成果。故本文就Fas及其泌尿系肿瘤的关系做一综述。 Apoptosis is one of the main modes of regulation in the body’s elimination of infections, mutations, and senescent cells while maintaining their physiological state. Fas is a transmembrane protein that, after binding to the corresponding ligand, activates the intrinsic death process of the target cell and causes the cell to undergo apoptosis. Studies have shown that the occurrence of malignant tumors is closely related to apoptosis. It may be due to the inhibition of apoptosis in normal physiological conditions, resulting in a positive imbalance in cell number. At present, the induction of apoptosis has become a new idea for cancer therapy, and preliminary results have been achieved. Therefore, this article reviews the relationship between Fas and its urinary tumors.