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目的探讨克罗米芬(CC)与来曲唑(LE)对多囊卵巢综合征(PCOS)患者促排卵效果及其妊娠的影响。方法选取2013年12月—2015年12月大邑县妇幼保健院收治的PCOS患者64例,随机将患者分为CC组(33例)和LE组(31例)。CC组口服CC治疗,LE组口服LE治疗,比较两组患者促排卵情况(包括完成的促排卵周期、有排卵周期、子宫内膜厚度、成熟卵泡数、最大卵泡直径)、治疗后临床妊娠情况(包括正常妊娠、流产以及多胎妊娠)及临床妊娠者平均用药周期。结果 CC组患者排卵周期高于LE组,差异有统计学意义(P<0.05);CC组患者人绒毛膜促性腺激素(HCG)日监测到的成熟卵泡个数多于LE组,但LE组患者子宫内膜厚度厚于CC组,差异有统计学意义(P<0.05)。两组正常妊娠率比较,差异无统计学意义(P>0.05);两组流产和多胎妊娠率比较,差异无统计学意义(P>0.05);CC组临床妊娠者治疗周期短于LE组,差异有统计学意义(P<0.05)。结论 CC与LE对PCOS患者促排卵效果和妊娠情况各有特点,但整体上疗效较为相似。
Objective To investigate the effect of clomiphene citrate (CC) and letrozole (LE) on ovulation induction and pregnancy in patients with polycystic ovary syndrome (PCOS). Methods Sixty-four patients with PCOS who were treated in Dayi County Maternal and Child Health Hospital from December 2013 to December 2015 were randomly divided into CC group (33 cases) and LE group (31 cases). CC group oral CC treatment, LE group oral LE treatment, the two groups of patients with ovulation (including the completion of the ovulation cycle, ovulation cycle, endometrial thickness, the number of mature follicles, the largest follicle diameter), clinical pregnancy after treatment (Including normal pregnancy, abortion and multiple pregnancy) and clinical pregnancy average medication cycle. Results The ovulation period in CC group was higher than that in LE group (P <0.05). The number of mature follicles monitored by human chorionic gonadotropin (HCG) day in CC group was more than that in LE group, but the LE group The thickness of endometrium in patients was thicker than that in CC group (P <0.05). There was no significant difference between the two groups in the normal pregnancy rate (P> 0.05). There was no significant difference in the pregnancy rates between the two groups (P> 0.05) The difference was statistically significant (P <0.05). Conclusions CC and LE have different effects on ovulation induction and pregnancy in patients with PCOS, but the overall effect is similar.